| |
Publications & Reviews Dr. Mark Brian Anderson, PhD.
THERAPEUTIC AREAS:
Drug discovery & development experience in cancer/oncology; infectious diseases; neurology; adverse drug reactions; neurodegeneration;
multiple kinase targets; antivirals, HIV, genetic, epigenetic and metabolic targets; bacterial and fungal targets; thrombosis;
endocrine; cardiovascular; inflammation, cell adhesion, pulmonary, chemical biology, chemical proteomics, vascular disrupting
and vascular targeting agents, tubulin agents, Alzheimer's disease, and ischemia-reperfusion inhibitors.
PUBLICATIONS HIGHLIGHTS: 50+ publications on novel agents
with potent anti-maturation activity against HIV-1, discovery of novel agents for treating brain cancer, SAR of novel anticancer
agents, experimental therapeutics, new methodologies, etc., additional publications are in progress. Examples: 2008 review
on vascular disrupting and vascular targeting agents (in press), 2003 Annual Reports in Medicinal Chemistry, Burger's Medicinal
Chemistry Chapter 22 (1994), ACS and international symposia posters, and many international collaboration presentations.
2009 - AACR
Poster #5569
Christopher M. Pleiman, Adam Willardsen, In Chul Kim, Warren S. Weiner, Chad Bradford, Bruce Roth,
Harry Austin, Robert J. Halter, Chris Jolley, Gary Mather, Kenton Zavitz, Mark
Anderson, Joshua Jones and Robert O. Carlson. Characterization of an orally bioavailable homolog of MPC-6827 (MPI-443803)
that maintains high brain penetration. AACR 100th Meeting April 18-22, 2009.
Denver, CO. Poster #5569. (drug design, drug discovery, blood brain barrier, SAR, SXR, cancer, tumor, synthesis, oral, bioavailable,
pharmacokinetics, pharmacodynamics, ADME).
2009 - Current
Bioactive Compounds (Review)
Paul R. Sebahar, J. Adam Willardsen
and Mark B. Anderson. Anticancer Agents: VTA or VDA. Current Bioactive Compounds,
2009, 5(1), 79-97. (vascular disrupting agents, vascular targeting agents, tumor, cancer, drug design, drug
discovery, review). WEBLINK - http://www.ingentaconnect.com/content/ben/cbc/2009/00000005/00000001/art00005
2009 - AACR Poster #2706
AACR Poster March 30,
2009. Nilantha Sirisoma, Azra Pervin, Hong Zhang, Songchun Jiang, J. Adam Willardsen, Mark B. Anderson, Gary Mather, Christopher
M. Pleiman, Shailaja Kasibhatla, Ben Tseng, John Drewe, Sui Xiong Cai. Discovery of N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine,
MPC-6827, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration. AACR
2009 Abstract #2706. (drug design, drug discovery, blood brain barrier, SAR, SXR, cancer, tumor, synthesis, oral, bioavailable,
pharmacokinetics, pharmacodynamics, ADME).
2009 - Journal
of Medicinal Chemistry
Nilantha Sirisoma, Azra Pervin, Hong Zhang,
Songchun Jiang, J. Adam Willardsen, Mark B. Anderson, Gary Mather, Christopher M. Pleiman, Shailaja Kasibhatla, Ben Tseng,
John Drewe, Sui Xiong Cai. DISCOVERY OF N-(4-METHOXYPHENYL)-N,2-DIMETHYLQUINAZOLIN-4-AMINE, A POTENT APOPTOSIS INDUCER
AND EFFICACIOUS ANTICANCER AGENT WITH HIGH BLOOD BRAIN BARRIER PENETRATION. J. Med. Chem., 2009,
52 (8), 2341-2351. WEBLINK - http://pubs.acs.org/doi/abs/10.1021/jm801315b DOI: 10.1021/jm801315b web publication date 18 March 2009. (drug
design, drug discovery, blood brain barrier, SAR, SXR, cancer, tumor, synthesis, oral, bioavailable, pharmacokinetics, pharmacodynamics,
ADME).
2008 - Bioorganic
& Medicinal Chemistry Letters
David Gerrish, In Chul Kim, Dange V. Kumar, Harry Austin, Jennifer E. Garrus,
Vijay Baichwal, Michael Saunders, Rena S. McKinnon, Mark B. Anderson, Robert Carlson, Esther Arranz-Plaza, Kraig M. Yager.
TRITERPENE BASED COMPOUNDS WITH POTENT ANTI-MATURATION ACTIVITY AGAINST HIV-. Bioorganic & Medicinal
Chemistry Letters 18 (2008) 6377-6380. (drug design, drug discovery, SAR, SXR, HIV, antiviral, synthesis, pharmacokinetics,
pharmacodynamic considerations, ADME).
2008 - Journal of Medicinal Chemistry
Nilantha Sirisoma, Shailaja Kasibhatla, Azra Pervin,
Hong Zhang, Songchun Jiang, J. Adam Willardsen, Mark Anderson, Christopher M. Pleiman, Ben Tseng, John Drewe, Sui Xiong Cai.
DISCOVERY OF 2-CHLORO-N-(4-METHOXYPHENYL)-N-METHYLQUINAZOLIN-4-AMINE (EP128265, MPI-0441138) AS AN INDUCER OF APOPTOSIS
WITH IN VIVO ACTIVITY. J. Med. Chem. 2008, 51, 4771-4779. (drug design, drug discovery, blood brain
barrier, SAR, SXR, cancer, tumor, synthesis, oral, bioavailable, pharmacokinetics, pharmacodynamics, ADME). WEBLINK - http://pubs.acs.org/doi/abs/10.1021/jm8003653
2008 - ACS Poster MEDI-101
Cai, Sui Xiong; Sirisoma, Nilantha; Pervin, Azra; Zhang, Hong; Jiang, Songchun; Baichwal, Vijay;
Willardsen, J. Adam; Anderson, Mark; Pleiman, Christopher M.; Tseng, Ben; Kasibhatla, Shailaja; Drewe, John. DISCOVERY
OF 2-CHLORO-N-(4-METHOXYPHENYL)-N-METHYLQUINAZOLIN-4-AMINE (EP128265, MPI-0441138) AS A POTENT APOPTOSIS INDUCER USING ANTICANCER
SCREENING APOPTOSIS PROGRAM (ASAP), A CELL- AND CASPASE-BASED PLATFORM. Abstracts of Papers, 235th ACS National Meeting,
New Orleans, LA, United States, April 6-10, 2008 (2008), MEDI-101. CODEN: 69KNN3 AN 2008:389655. (drug design, drug discovery,
blood brain barrier, SAR, SXR, cancer, tumor, synthesis, oral, bioavailable). (drug design, drug discovery, blood brain barrier,
SAR, SXR, cancer, tumor, synthesis, oral, bioavailable, pharmacokinetics).
2008 - AACR Poster #1265
Nilantha Sirisoma, Azra Pervin,
Hong Zhang, Songchun Jiang, Vijay Baichwal, J. Adam Willardsen, Mark Anderson, Christopher M. Pleiman, Ben Tseng, Shailaja
Kasibhatla, John Drewe, Sui Xiong Cai. 2-CHLORO-N-(4-METHOXYPHENYL)-N-METHYLQUINAZOLIN-4-AMINE (EP128265, MPI-0441138)
AS AN INDUCER OF APOPTOSIS WITH IN VIVO ACTIVITY. AACR April 12-16, 2008, San Diego, California, 99th Meeting Abstract
# 1265. (drug design, drug discovery, blood brain barrier, SAR, SXR, cancer, tumor, synthesis, oral, bioavailable,pharmacokinetics,
pharmacodynamics, ADME).
2007 - Purdue University Invited Lecture
on Neurodegenerative and Alzheimer's disease
Anderson, Mark B. Invited
Lecture for the Purdue University Special Topics Presentation: ALZHEIMER'S DISEASE - TARGETING AMYLOID. October
5th, 2007, West Lafayette, Indiana. (Alzheimer's, SXR, SAR, drug design, drug discovery, competitive analysis,
review).
2006 - Journal of Medicinal Chemistry
Li, Haitao; Anderes, Kenna L.; Kraynov, Eugenia A.; Luthin, David R.; Do, Quyen-Quyen; Hong,
Yufeng; Tompkins, Eileen; Sun, Eric T.; Rajapakse, Ranjan; Pathak, Ved P.; Christie, Lance C.; Vazir, Haresh; Castillo, Rosemary;
Gregory, Margaret L.; Castro, Mary; Nared-Hood, Karen; Paderes, Genevieve; Anderson, Mark B.. DISCOVERY OF A NOVEL,
ORALLY ACTIVE, SMALL MOLECULE GONADOTROPIN-RELEASING HORMONE (GNRH) RECEPTOR ANTAGONIST. [ERRATUM TO DOCUMENT CITED IN CA145:020415].
Journal of Medicinal Chemistry (2006), 49(19), 5849. CODEN: JMCMAR ISSN:0022-2623. CAN 145:347819 AN 2006:844175. (drug design,
drug discovery, blood brain barrier, SAR, SXR, cancer, tumor, synthesis, oral, bioavailable, pharmacokinetics, pharmacodynamics,
ADME). WEBLINK - http://pubs.acs.org/doi/abs/10.1021/jm060975f
2006 - Journal of Medicinal Chemistry
Li, Haitao; Anderes, Kenna L.; Kraynov, Eugenia A.; Luthin, David R.; Do, Quyen-Quyen; Hong, Yufeng;
Tompkins, Eileen; Sun, Eric T.; Rajapakse, Ranjan; Pathak, Ved P.; Christie, Lance C.; Vazir, Haresh; Castillo, Rosemary;
Gregory, Margaret L.; Castro, Mary; Nared-Hood, Karen; Paderes, Genevieve; Anderson, Mark B.. DISCOVERY OF A NOVEL,
ORALLY ACTIVE, SMALL MOLECULE GONADOTROPIN-RELEASING HORMONE (GNRH) RECEPTOR ANTAGONIST. Journal of Medicinal Chemistry
(2006), 49(11), 3362-3367. CODEN: JMCMAR ISSN:0022-2623. CAN 145:20415 AN 2006:376441. (drug design, drug discovery, blood
brain barrier, SAR, SXR, cancer, tumor, synthesis, oral, bioavailable, pharmacokinetics, pharmacodynamics, ADME). WEBLINK - http://pubs.acs.org/doi/abs/10.1021/jm060012g
2003 - Journal of Pharmacology and Experimental Therapeutics
Anderes, Kenna L.; Luthin, David R.; Castillo, Rosemary; Kraynov, Eugenia A.; Castro, Mary; Nared-Hood, Karen;
Gregory, Margaret L.; Pathak, Ved P.; Christie, Lance C.; Paderes, Genevieve; Vazir, Haresh; Ye, Qiang; Anderson, Mark B.;
May, John M. BIOLOGICAL CHARACTERIZATION OF A NOVEL, ORALLY ACTIVE SMALL MOLECULE GONADOTROPIN-RELEASING HORMONE (GNRH)
ANTAGONIST USING CASTRATED AND INTACT RATS. Journal of Pharmacology and Experimental Therapeutics (2003), 305(2),
688-695. CODEN: JPETAB ISSN:0022-3565. CAN 139:270462 AN 2003:329596. (drug design, drug discovery, blood brain barrier, SAR,
SXR, cancer, tumor, synthesis, oral, bioavailable, pharmacokinetics, pharmacodynamics, ADME, chemical biology).
WEBLINK - http://jpet.aspetjournals.org/cgi/content/abstract/305/2/688
2003 - Journal of Organic Chemistry
Shackelford, Scott A.; Anderson, Mark B.; Christie, Lance C.; Goetzen, Thomas; Guzman, Mark C.; Hananel, Martha
A.; Kornreich, Wayne D.; Li, Haitao; Pathak, Ved P.; Rabinovich, Alex K.; Rajapakse, Ranjan J.; Truesdale, Larry K.; Tsank,
Stella M.; Vazir, Haresh N. ELECTROPHILIC TETRAALKYLAMMONIUM NITRATE NITRATION. II. IMPROVED ANHYDROUS AROMATIC AND
HETEROAROMATIC MONONITRATION WITH TETRAMETHYLAMMONIUM NITRATE AND TRIFLIC ANHYDRIDE, INCLUDING SELECTED MICROWAVE EXAMPLES.
Journal of Organic Chemistry (2003), 68(2), 267-275. CODEN: JOCEAH ISSN:0022-3263. CAN 138:169603 AN 2002:943438. Note erratum
to CA138:169603 Journal of Organic Chemistry (2003), 68(7), 2986. CODEN: JOCEAH ISSN:0022-3263. CAN 140:41589 AN 2003:135779.
(drug design, drug discovery, SAR, SXR, synthesis, nitration).
WEBLINK - http://www.ucm.es/BUCM/compludoc/W/10308/00223263_5.htm
2003 - Annual Reports in Medicinal Chemistry (Review)
Anderson, Mark B.; Roemer, Terry; Fabrey, Robyn. PROGRESS IN ANTIFUNGAL DRUG DISCOVERY.
Annual Reports in Medicinal Chemistry (2003), 38 163-172. CODEN: ARMCBI ISSN:0065-7743. CAN 140:228118 AN 2003:836070. (antiinfective,
infective, fungal, review).
2002 - Pharmaceutical Research
Iatsimirskaia, Eugenia A.; Gregory, Margaret L.; Anderes, Kenna L.; Castillo, Rosemary; Milgram,
K. Eric; Luthin, David R.; Pathak, Ved P.; Christie, Lance C.; Vazir, Haresh; Anderson, Mark B.; May, John M. EFFECT
OF TESTOSTERONE SUPPRESSION ON THE PHARMACOKINETICS OF A POTENT GNRH RECEPTOR ANTAGONIST. Pharmaceutical Research
(2002), 19(2), 202-208. CODEN: PHREEB ISSN:0724-8741. CAN 137:73535 AN 2002:200606. (drug design, drug discovery, SAR, SXR,
cancer, tumor, synthesis, oral, bioavailable, pharmacokinetics, pharmacodynamics, ADME).
2002 - Bioorganic & Medicinal Chemistry Letters
Luthin,
David R.; Hong, Yufeng; Tompkins, Eileen; Anderes, Kenna L.; Paderes, Genevieve; Kraynov, Eugenia A.; Castro, Mary A.; Nared-Hood,
Karen D.; Castillo, Rosemary; Gregory, Margaret; Vazir, Haresh; May, John M.; Anderson, Mark B. CHARACTERIZATION OF
MONO- AND DIAMINOPYRIMIDINE DERIVATIVES AS NOVEL, NONPEPTIDE GONADOTROPIN RELEASING HORMONE (GNRH) RECEPTOR ANTAGONISTS.
Bioorganic & Medicinal Chemistry Letters (2002), 12(24), 3635-3639. CODEN: BMCLE8 ISSN:0960-894X. CAN 139:17096 AN 2002:878755.
(drug design, drug discovery, SAR, SXR, cancer, tumor, synthesis, bioavailable, pharmacokinetics, pharmacodynamics, ADME,
chemical biology).
WEBLINK - http://www.ingentaconnect.com/content/els/0960894x/2002/00000012/00000024/art00756
2002 - Bioorganic & Medicinal Chemistry Letters
Luthin, David R.; Hong, Yufeng; Pathak, Ved P.; Paderes, Genevieve; Nared-Hood,
Karen D.; Castro, Mary A.; Vazir, Haresh; Li, Haitao; Tompkins, Eileen; Christie, Lance; May, John M.; Anderson, Mark B. THE
DISCOVERY OF NOVEL SMALL MOLECULE NON-PEPTIDE GONADOTROPIN RELEASING HORMONE (GNRH) RECEPTOR ANTAGONISTS. Bioorganic
& Medicinal Chemistry Letters (2002), 12(23), 3467-3470. CODEN: BMCLE8 ISSN:0960-894X. CAN 138:378559 AN 2002:846220.
(drug design, drug discovery, SAR, SXR, cancer, tumor, synthesis, pharmacokinetics, pharmacodynamics, ADME).
2001 - Combinatorial Chemistry Symposium
M. B.
Anderson, V. Pathak, Y. Hong, L. Christie, R. Rajapakse, Q. Do, H. Li, E. Tompkins, J. Feng, D. Luthin, K. Nareed-Hood, M.
Castro, S. Barnum , J. May, E. Iatsimirskaia, M. Gregory, Kenna Anderes, R. Castillo, G. Paderes. THE POWER OF MEDICINAL
& COMBINATORIAL CHEMISTRIES IN DRUG DISCOVERY--AN ILLUSTRATION. UCSD San Diego Combinatorial Chemistry Symposium,
CA 13 July 2001. (drug design, drug discovery, SAR, SXR, combinatorial, synthesis)
2001 - Australia Peptide Symposium Poster
Haitao
Li, Quyen-Quyen Do, Yufeng Hong, Eileen Tompkins, Ved Pathak, Lance Christie, David Luthin, Genevieve Paderes, Haresh Vazir,
and Mark B Anderson. DISCOVERY AND OPTIMIZATION OF POTENT SMALL MOLECULE GNRH (GONADOTROPIN RELEASING HORMONE) ANTAGONISTS
4th Australia Peptide Symposium Poster Oct 7-12 2001. (drug design, drug discovery, synthesis, SAR, SXR).
2000 - Society of Toxicology
M. B. Anderson, V. Pathak, Y. Hong, L. Christie, R. Rajapakse, Q. Do, H. Li, E. Tompkins, J. Feng, D. Luthin, K.
Nareed-Hood, M. Castro, S. Barnum , J. May, E. Iatsimirskaia, M. Gregory, Kenna Anderes, R. Castillo, G. Paderes. THE
POWER OF PARALLEL MEDICINAL CHEMISTRY IN DRUG DISCOVERY--AN ILLUSTRATION. Society of Toxicology, Irvine, CA 6 June
2000. (drug design, drug discovery, synthesis, SAR, SXR, review).
1998
- Journal of Pharmacology and Experimental Therapeutics
Kilgore, Kenneth
S.; Powers, Karen L.; Imlay, Michelle M.; Malani, Anu; Allen, Douglas I.; Beyer, Jennifer T.; Anderson, Mark B.; Warren, Jeffrey
S. THE CARBOHYDRATE SIALYL LEWISX (SLEX) SULFATED GLYCOMIMETIC GM2941 ATTENUATES GLUCAN-INDUCED PULMONARY GRANULOMATOUS
VASCULITIS IN THE RAT. Journal of Pharmacology and Experimental Therapeutics (1998), 286(1), 439-446. CODEN: JPETAB
ISSN:0022-3565. CAN 129:184095 AN 1998:454322. http://jpet.aspetjournals.org/cgi/content/full/284/1/427 (drug design, drug
discovery, synthesis, SAR, SXR, pulmonary, lung, disease). WEBLINK - http://jpet.aspetjournals.org/cgi/content/abstract/286/1/439
1998 - Journal of Pharmacology and Experimental Therapeutics
Kilgore, Kenneth S.; Tanhehco, Elaine J.; Park, James L.; Naylor, Keith B.; Anderson, Mark
B.; Lucchesi, Benedict R. REDUCTION OF MYOCARDIAL INFARCT SIZE IN VIVO BY CARBOHYDRATE-BASED GLYCOMIMETICS.
Journal of Pharmacology and Experimental Therapeutics (1998), 284(1), 427-435. CODEN: JPETAB ISSN:0022-3565. CAN 128:212667
AN 1998:53500. http://jpet.aspetjournals.org/cgi/content/full/284/1/427 (drug design, drug discovery, synthesis, SAR, SXR,
cardiovascular). WEBLINK - http://jpet.aspetjournals.org/cgi/content/abstract/284/1/427
1998 - American Journal of Respiratory Cell and Molecular Biology
Kim, Mi-Kyeong; Brandley, Brian K.; Anderson, Mark B.; Bochner, Bruce
S. ANTAGONISM OF SELECTIN-DEPENDENT ADHESION OF HUMAN EOSINOPHILS AND NEUTROPHILS BY GLYCOMIMETICS AND OLIGOSACCHARIDE
COMPOUNDS. American Journal of Respiratory Cell and Molecular Biology (1998), 19(5), 836-841. CODEN: AJRBEL ISSN:1044-1549.
CAN 130:123771 AN 1998:758109. (drug design, drug discovery, synthesis, SAR, SXR, pulmonary). WEBLINK - http://ajrcmb.atsjournals.org/cgi/content/abstract/19/5/836
1998 - Journal of Pharmacology and Experimental Therapeutics
Kilgore, Kenneth S.; Powers, Karen L.; Imlay, Michelle M.; Malani,
Anu; Allen, Douglas I.; Beyer, Jennifer T.; Anderson, Mark B.; Warren, Jeffrey S. THE CARBOHYDRATE SIALYL LEWISX (SLEX)
SULFATED GLYCOMIMETIC GM2941 ATTENUATES GLUCAN-INDUCED PULMONARY GRANULOMATOUS VASCULITIS IN THE RAT. Journal of
Pharmacology and Experimental Therapeutics (1998), 286(1), 439-446. CODEN: JPETAB ISSN:0022-3565. CAN 129:184095 AN 1998:454322.
(drug design, drug discovery, synthesis, SAR, SXR).
WEBLINK - http://jpet.aspetjournals.org/cgi/content/abstract/286/1/439
1998 - Journal of Pharmacology and Experimental Therapeutics
Kilgore, Kenneth S.; Tanhehco, Elaine J.; Park, James L.; Naylor, Keith
B.; Anderson, Mark B.; Lucchesi, Benedict R. REDUCTION OF MYOCARDIAL INFARCT SIZE IN VIVO BY CARBOHYDRATE-BASED GLYCOMIMETICS.
Journal of Pharmacology and Experimental Therapeutics (1998), 284(1), 427-435. CODEN: JPETAB ISSN:0022-3565. CAN 128:212667
AN 1998:53500. (drug design, drug discovery, synthesis, SAR, SXR). WEBLINK - http://jpet.aspetjournals.org/cgi/content/abstract/284/1/427
1998 - ISHR XX Annual Meeting
Anderson, M.B., Lucchesi, B.R., Kilgore, K.S., et al., INHIBITORS OF SELECTIN-MEDIATED CELL ADHESION.
New Frontiers in Cardiovascular Research, International Society for Heart Research (ISHR) XX Annual Meeting, University
of Michigan, Ann Arbor, Michigan August 9-12, 1998. (drug design, drug discovery, synthesis, SAR, SXR).
1998 - ISHR XX Annual Meeting
Powers,
K.L., Kilgore, K.S., Anderson, M.B., Warren, J.S. STRUCTURAL ANALYSIS OF GLYCOMIMETIC INHIBITORS OF P-SELECTIN-MEDIATED
NEUTROPHIL ADHESION. NEW FRONTIERS IN CARDIOVASCULAR RESEARCH, INTERNATIONAL SOCIETY FOR HEART RESEARCH (ISHR) XX ANNUAL MEETING,
UNIVERSITY OF MICHIGAN, ANN ARBOR, MICHIGAN August 9-12, 1998. See Journal of Molecular and Cellular Cardiology,
1998, 30(7), A233 poster 2. (drug design, drug discovery, synthesis, SAR, SXR).
1998 - American Journal of Respiratory Cell and Molecular Biology
Kim,
Mi-Kyeong; Brandley, Brian K.; Anderson, Mark B.; Bochner, Bruce S. ANTAGONISM OF SELECTIN-DEPENDENT ADHESION OF HUMAN
EOSINOPHILS AND NEUTROPHILS BY GLYCOMIMETICS AND OLIGOSACCHARIDE COMPOUNDS. American Journal of Respiratory Cell
and Molecular Biology (1998), 19(5), 836-841. CODEN: AJRBEL ISSN:1044-1549. CAN 130:123771 AN 1998:758109. (drug design, drug
discovery, synthesis, SAR, SXR).
1998 - Additional Information
Anderson, M.B., Kilgore, K.S., et al. ADDITIONAL NOVEL GLYCOMIMETICS THAT ATTENUATED GLUCAN-INDUCED PULMONARY GRANULOMATOUS VASCULITIS IN
THE RAT. UNPUBLISHED.
1997 - Poster & Lecture
Lucchesi, B.R., Kilgore, K.S., Anderson,
M.B., et al REDUCTION OF MYOCARDIAL INFARCT SIZE IN VIVO BY GLYCOMIMETICS. American Heart Association
(AHA) San Diego, CA 1997. (drug design, drug discovery, synthesis, SAR, SXR, cardiovascular).
1997 - Journal of Surgical Research
Garcia-Criado,
F. J.; Palma-Vargas, J. M.; Valdunciel-Garcia, J. J.; Gomez-Alonso, A.; Srivastava, O.; Ezrin, A.; Anderson, M. B.; Toledo-Pereyra,
L. H. SULFO-LEWISX DIMINISHES NEUTROPHIL INFILTRATION AND FREE RADICALS WITH MINIMAL EFFECT ON SERUM CYTOKINES AFTER
LIVER ISCHEMIA AND REPERFUSION. Journal of Surgical Research (1997), 70(2), 187-194. CODEN: JSGRA2 ISSN:0022-4804.
CAN 127:219160 AN 1997:545222. (drug design, drug discovery).
1996
- Tokyo, Japan
Anderson, Mark B and guest. Presentations on cell adhesion
and new in vivo pulmonary model related to cell adhesion events. Sankyo Co., Tokyo, Japan.
1996 - Pharmaceutical News
Musser, John
H.; Anderson, Mark B.; Fugedi, Peter. GLYCOMIMETICS: AN APPROACH TO DISCOVERING LEADS FOR NOVEL THERAPEUTICS.
Pharmaceutical News (1996), 3(5), 11-17. CODEN: PHNEEP ISSN:1071-894X. CAN 126:54385 AN 1997:38145. (drug discovery, review).
1996 - International Medicinal Chemistry Symposium Poster
Anderson, M. B., Kilgore, K, FROM THE PHARAOH'S TOMB TO THE PHARMACY. International
Medicinal Chemistry Symposium, September 1996. (drug discovery, drug design)
1996
- Drug News & Perspectives
Musser, John H.; Fugedi, Peter; Anderson,
Mark Brian; Rao, Narasinga; Peto, Csaba; Tyrrell, Dave; Holme, Kevin; Tressler, Rob. CARBOHYDRATES AS A SOURCE OF
MOLECULAR DIVERSITY FOR DRUG DISCOVERY. Drug News & Perspectives (1996), 9(3), 133-141. CODEN: DNPEED ISSN:0214-0934.
CAN 126:98689 AN 1997:30187. (drug design, drug discovery, review).
1996
- ACS Pacific Regional Conference
Anderson, M.B., Lucchesi, B.R., Kilgore,
K.S., et al GLYCOMIMETICS AND GRANULOMATOUS VASCULITIS. ACS Pacific Regional Conference, San Francisco, October
1996.
1995 - J Allergy Clinical Immunology
M. K. Kim, B. K. Brandley, M. B. Anderson and B. S. Bochner, ANTAGONISM OF HUMAN NEUTROPHIL
(NEU) AND EOSINOPHIL (EOS) ADHESION BY GLYCOMIMETICS AND OLIGOSACCHARIDE COMPOUNDS. The American Academy of Allergy
and Immunology, abstract in J. Allergy Clin Immunol., 1995, 95:220. (drug design, drug discovery, synthesis, SAR).
1995 - Current Pharmaceutical Design
Musser,
John H.; Anderson, Mark B.; Levy, Daniel E. GLYCOMIMETICS AS SELECTIN INHIBITORS. Current Pharmaceutical
Design (1995), 1(2), 221-32. CODEN: CPDEFP ISSN:1381-6128. CAN 124:193057 AN 1996:90745. (drug design, drug discovery, review).
1994 - XVIIth International Carbohydrate Symposium
B. N. Narasinga Rao, M. B. Anderson, J. H. Musser, J. H. Gilbert, M. E. Schaefer, C. Foxall
and B. K. Brandley, IDENTIFICATION OF NOVEL SELECTIN INHIBITORS USING SLEX PHARMACOPHORE BASED SEARCH.
XVIIth International Carbohydrate Symposium, July 17‑22, 1994, Ottawa, Canada. (drug design, drug discovery).
1994 - Journal of Biological Chemistry
Rao,
B. N. Narasinga; Anderson, Mark B.; Musser, John H.; Gilbert, James H.; Schaefer, Mary E.; Foxall, Carrol; Brandley, Brian
K. SIALYL LEWIS X MIMICS DERIVED FROM A PHARMACOPHORE SEARCH ARE SELECTIN INHIBITORS WITH ANTI-INFLAMMATORY ACTIVITY.
Journal of Biological Chemistry (1994), 269(31), 19663-6. CODEN: JBCHA3 ISSN:0021-9258. CAN 121:148348 AN 1994:548348. (drug
design, drug discovery, synthesis, SAR, SXR, inflammation, chemical biology).
1994
- International Business Communications Presentation
Anderson, M. B.,
GLYCOMIMETIC INHIBITORS OF SELECTINS. TARGETING CELL ADHESION MOLECULES FOR THERAPEUTIC APPLICATION. Sheraton
Society Hill Hotel Philadelphia, PA. International Business Communications. December 1‑2, 1994. (drug design, drug discovery,
SAR, SXR).
1994 - Immunological Implications of Shock, Trauma and
Sepsis
B. K. Brandley, N. Rao, M. B. Anderson, H. Lopez, STRATEGIES
FOR THE DESIGN AND USE OF CARBOHYDRATES AND THEIR DERIVATIVES AS ANTI‑INFLAMMATORY THERAPEUTICS. For a Meeting
on Immunological Implications of Shock, Trauma and Sepsis in Munich, March 2‑6, 1994. (drug design, drug discovery,
shock, trauma, sepsis).
1994 - Burger's Medicinal Chemistry Chapter
22
John H. Musser, Péter Fügedi and Mark Brian Anderson.
CHAPTER TWENTY‑TWO: CARBOHYDRATE BASED THERAPEUTICS. Burger's Medicinal Chemistry, Fifth Edition 1994,
pages 901‑947. (drug design, drug discovery, review).
1991
- Tetrahedron Letters
Anderson, M. B.; Lamothe, M.; Fuchs, P. L. SYNTHESIS
VIA VINYL SULFONES. 41. CYTOCHALASIN, NATURAL PRODUCT SUPPORT STUDIES. 16. INTRAMOLECULAR ACYLATION OF AN
ALPHA-SULFONYL ANION GENERATED VIA HALOGEN-METAL EXCHANGE OF AN ALPHA-HALOSULFONE BEARING AN UNSYMMETRICAL
ANHYDRIDE. Tetrahedron Letters (1991), 32(35), 4457-60. CODEN: TELEAY ISSN:0040-4039. CAN 115:255658 AN 1991:655658.
(synthesis, cytochalasin, natural product).
1991 - Synthetic Communications
Lamothe, M.; Anderson, M. B.; Fuchs, P. L. SYNTHESIS VIA VINYL SULFONES.
40. CYTOCHALASIN, NATURAL PRODUCT SUPPORT STUDIES. 15. SCOPE AND LIMITATIONS IN THE USE OF ALPHA-SILYL AND
ALPHA-STANNYL SULFONES AS LATENT ALPHA-SULFONYL ANIONS. Synthetic Communications (1991), 21(15-16), 1675-93. CODEN:
SYNCAV ISSN:0039-7911. CAN 115:255715 AN 1991:655715. (synthesis, cytochalasin, natural product).
1990 - Rapid Commun Mass Spectrom
Wood,
K. V.; Rothwell, A. P.; Anderson, M. B.; Fuchs, P. L. THE INTRAMOLECULAR MIGRATION OF A TRIMETHYLSILYL GROUP LOCATED
ALPHA TO A SULFONE IN SUBSTITUTED CYCLOHEXYL SYSTEMS. Rapid Communications in Mass Spectrometry (1990), 4(1), 1-4.
CODEN: RCMSEF ISSN:0951-4198. CAN 114:6582 AN 1991:6582. (synthesis, cytochalasin, natural product).
1990 - Organic Mass Spectrometry
Wood,
K. V.; Rothwell, A. P.; Anderson, M. B.; Lamothe, M.; Fuchs, P. L. MASS SPECTRA OF SUBSTITUTED O-TRIMETHYLSILYLPHENYL
SULFONES. Organic Mass Spectrometry (1990), 25(8), 423-5. CODEN: ORMSBG ISSN:0030-493X. CAN 114:6593 AN 1991:6593.
(synthesis, cytochalasin, natural product).
1990 - Journal of Organic
Chemistry
Anderson, M. B.; Fuchs, P. L. SYNTHESIS VIA VINYL SULFONES.
37. CYTOCHALASIN, NATURAL PRODUCT SUPPORT STUDIES. 11. ALPHA-SILYL SULFONES AS LATENT ALPHA-SULFONYL ANIONS.
FLUORIDE-PROMOTED INTRAMOLECULAR 1,2-ADDITIONS TO ALDEHYDES AS THE BASIS OF A NEW CYCLOPENTENYLATION STRATEGY. Journal
of Organic Chemistry (1990), 55(1), 337-42. CODEN: JOCEAH ISSN:0022-3263. CAN 112:35729 AN 1990:35729. (synthesis, cytochalasin,
natural product).
1989 - Purdue Thesis
Anderson, Mark Brian. NEW METHODOLOGIES DIRECTED TOWARDS THE TOTAL SYNTHESIS OF CYTOCHALASIN,
NATURAL PRODUCT C AND D. (1989), 498 pp. CAN 114:101467 AN 1991:101467. (synthesis, cytochalasin, natural product).
1988 - Rapid Commun Mass Spectrom
Wood, Karl V.; Rothwell, Arlene P.; Anderson, Mark B.; Fuchs, P. L. EVIDENCE FOR COMPETITIVE INTRAMOLECULAR
TRIMETHYLSILYL REARRANGEMENT TO OXYGEN AND SULFUR IN BETA-TRIMETHYLSILYLETHYLTHIOL ESTERS. Rapid Communications in
Mass Spectrometry (1988), 2(2), 38-40. CODEN: RCMSEF ISSN:0951-4198. CAN 112:35953 AN 1990:35953. (synthesis, cytochalasin,
natural product).
1988 - Journal of Organic Chemistry
Anderson, M. B.; Ranasinghe, M. G.; Palmer, J. T.; Fuchs, P. L. CYTOCHALASIN, NATURAL PRODUCT
SUPPORT STUDIES. 10. NUCLEOPHILIC AND ELECTROPHILIC MERCAPTANYLATIONS VIA 2-(TRIMETHYLSILYL)ETHANETHIOL-DERIVED REAGENTS.
Journal of Organic Chemistry (1988), 53(13), 3125-7. CODEN: JOCEAH ISSN:0022-3263. CAN 109:170526 AN 1988:570526. (synthesis,
cytochalasin, natural product).
1987 - Synthetic Communications
Anderson, M. B.; Fuchs, P. L. CYTOCHALASIN, NATURAL PRODUCT
SUPPORT STUDIES. PART 9. AN EFFICIENT METHOD FOR CONVERSION OF CARBOXYLIC ACID DERIVATIVES TO ALLYLSILANES. Synthetic
Communications (1987), 17(6), 621-35. CODEN: SYNCAV ISSN:0039-7911. CAN 108:150550 AN 1988:150550. (synthesis, cytochalasin,
natural product).
Key Workds: consultant,
consulting, drug discovery strategies, drug discovery methods, Pharmaceutical consultant, Chemistry Consulting, Drug Discovery,
Drug Development, research and development, CRO, chemistry, medicinal chemistry, chemical biology, proteomics, Contract Research
Organization, CONSULTING, CHEMISTRY CONSULTING, PHARMACEUTICAL CONSULTING, DRUG DISCOVERY, DRUG DEVELOPMENT, RESEARCH AND
DEVELOPMENT, PHARMACEUTICAL CONSULTANT, CHEMISTRY, MEDICINAL CHEMISTRY, CONTRACT RESEARCH ORGANIZATION, CHEMICAL BIOLOGY,
cancer, cell adhesion, anti infectives, oncology, kinases, viral, neurodegeneration, genetic, epigenetic, metabolic targets,
infectious disease, pulminary, inflammation, thrombrosis, endocrine, and cardiovascular, CANCER, CELL ADHESION, ANTI INFECTIVES,
ONCOLOTY, ,KINASIS, NEURODEGENERATION, GENETIC, EPIGENETIC, PROTEOMICS, METABOLIC TARGETS, INFECTIOS DISEASE, PULMINARY, INFLAMMATIONS,
THROMBOSIS, ENDOCRINE, CARDIOVASCALUR, GNRH, APOPTOSIS, ANTIVIRAL, gnrh, apoptosis, antiviral, blood brain barrier, BLOOD
BRAIN BARRIER
|
|
