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Publications & Reviews
Mark Brian Anderson, PhD, RAC

THERAPEUTIC AREAS: Dr. Anderson brings drug discovery & development experience in cancer/oncology; infectious diseases; neurology; adverse drug reactions; neurodegeneration; multiple kinase targets; antivirals, HIV, genetic, epigenetic and metabolic targets; bacterial and fungal targets; thrombosis; endocrine; cardiovascular; inflammation, cell adhesion, pulmonary, chemical biology, chemical proteomics, vascular disrupting and vascular targeting agents, tubulin agents, Alzheimer's disease, and ischemia-reperfusion inhibitors.


PUBLICATIONS HIGHLIGHTS: 75+ peer reviewed publications on novel agents; discovery of novel agents for treating brain cancer, SAR of novel anticancer agents, experimental therapeutics, new methodologies, with potent anti-maturation activity against HIV-1, etc., additional publications are in progress.

Examples: 2008 review on vascular disrupting and vascular targeting agents, 2003 Annual Reports in Medicinal Chemistry, Burger's Medicinal Chemistry Chapter 22 (1994), ACS and international symposia posters, and many international collaboration presentations

Infectious Disease & Medical Devices

  
Submitted - Pathogenic bacterial biofilm manuscripts.
In Preparation - Nonclinical pathology manuscripts (2).

Andreas Jekle, Suriani Abdul Rani, Chris Celeri, Meghan Zuck, Ping Xu, Lu Wang, Kathryn Najafi, Mark Anderson, David Stroman and Dmitri Debabov. Broad-Spectrum Virucidal Activity of (NVC-422) N,N-dichloro-2,2-dimethyltaurine  against Viral Ocular Pathogens in vitro. 2013 IOVS (Investigative Ophthalmology & Visual Science) Accepted.

Accepted chapter in e-EROS Encyclopedia of Reagents for Organic Synthesis – Wiley.

John Crew, Randell Varilla, Thomas Allandale Rocas, Dmitri Debabov, Lu Wang, Azar Najafi, Suriani Abdul Rani, Ramin (Ron) Najafi, Mark Anderson. NeutroPhase® in chronic non-healing wounds. Int J Burn Trauma 2012; 2(3): 126-134.

Andreas Jekle, Jungjoo Yoon, Meghan Zuck, Ramin (Ron) Najafi, Lu Wang, Timothy Shiau, Charles Francavilla, Suriani Abdul Rani, Christian Eitzinger, Markus Nagl, Mark Anderson, and Dmitri Debabov. NVC-422 Inactivates Staphylococcus aureus Toxins. Antimicrob. Agents Chemother. published ahead of print 3 December 2012 , doi:10.1128/AAC.01945-12.

Eitzinger C., Ehrlenbach S., Lindner H., Kremser L., Gottardi W., Debabov, D., Anderson, M., Nagl, M., Orth, D. N-Chlorotaurine, a Long-Lived Oxidant Produced by Human Leukocytes, Inactivates Shiga Toxin of Enterohemorrhagic Escherichia coli. 2012 PLoS ONE 7(11): e47105. doi:10.1371/journal.pone.0047105

Teuchner, B., Eitzinger, C., Lutz, M., Hager, T., Schmid, E., Bechrakis, N. E., Zuck, M., Jekle, A., Debabov, D., Anderson, M. and Nagl, M. (12Sept2012; online), N-chlorotaurine and its analogues N,N-dichloro-2,2-dimethyltaurine and N-monochloro-2,2-dimethyltaurine are safe and effective bactericidal agents in ex vivo corneal infection models. Acta Ophthalmologica. doi: 10.1111/j.1755-3768.2012.02501.x

Deepti Singhal, Andreas Jekle, Dmitri Debabov, Lu Wang, Bez Khosrovi, Mark Anderson,  Andrew Foreman, and Peter-John Wormald. Efficacy of NVC-422 against Staphylococcus aureus biofilms in a sheep biofilm model of sinusitis. International Forum of Allergy & Rhinology, 2012, 2, 309-315.

Louisa D’Lima, Lisa Friedman, Lu Wang, Ping Xu, Mark Anderson and Dmitri Debabov. No Decrease in Susceptibility to NVC-422 in Multiple Passage Studies against MRSA, S. aureus, P. aeruginosa and E. coli. Antimicrobial Agents and Chemotherapy 2012, 56, 2753–2755. First published February 2012, doi: 10.1128/?AAC.05985-11. 

Martini, A. Hammerer-Lercher, M. Zuck, A. Jekle, D. Debabov, M. Anderson, M. Nagl. Antimicrobial and Anticoagulant Activity of N-chlorotaurine (NCT) N,N-dichloro-2,2-dimethyltaurine (NVC-422) and N-monochloro-2,2-dimethyltaurine (NVC-612) in Human Blood. Antimicrobial Agents and Chemotherapy 2012, 56(4):1979-1984. [Epub ahead of print], PMID: 22252818. 

 M.A. Ghannoum, L. Long, A.J. Cirino, A.R. Miller, R. Najafi, L. Wang, K. Sharma, M. Anderson, and B. Memarzadeh. Efficacy of NVC-422 in the treatment of dermatophytosis caused by Trichophyton mentagrophytes using a Guinea Pig Model. International Journal of Dermatology. In press 2012.

Rabih Darouiche, Ramin (Ron) Najafi, Kenneth Krantz, Dmitri Debabov, Lisa Friedman, Behzad Khosrovi, Lu Wang, Susan Iovino, Mark Anderson. NVC-422. Drugs of the Future 2011, 36(9): 651-656.

Susan M. Iovino, Kenneth D. Krantz, Daisy M. Blanco, Josefina A. Fernández, Naomi Ocampo, Azar Najafi, Bahram Memarzadeh, Chris Celeri, Dmitri Debabov, Behzad Khosrovi, and Mark Anderson. NVC-422 Topical Gel for the Treatment of Impetigo. International Journal of Clinical and Experimental Pathology. 2011; 4(6):587-595.

Yoon J, Jekle A, Najafi R, Ruado F, Zuck M, Khosrovi B, Memarzadeh B, Debabov D, Wang L, Anderson M. [Epub ahead of print; Oct 15] Virucidal mechanism of action of NVC-422, a novel antimicrobial drug for the treatment of adenoviral conjunctivitis. Yoon J, Jekle A, Najafi R, Ruado F, Zuck M, Khosrovi B, Memarzadeh B, Debabov D, Wang L, Anderson M. Antiviral Res. 2011; 92: 470–478. PMID: 22024427.

D. Debabov, C. Celeri, L. Friedman, R. Najafi, and M. Anderson. NVC-422 is Effective against Gram-positive and Gram-negative Pathogens including MDR Strains. Antimicrobial Agents and Chemotherapy. In Press 2012.

D. Debabov, C. Celeri, Lu Wang, Ping Xu, L. Friedman, D. Sahm, R. Najafi, and M. Anderson. In vitro Activity of NVC-422, a Unique, Broad Spectrum Antimicrobial Compound, against Key Gram-positive and Gram-negative Bacterial Pathogens. Accepted.

Andreas Jekle, Chris Celeri, Meghan Zuck, Ping Xu, Lu Wang, Mark Anderson and Dmitri Debabov. Activity of NVC-422 against Viral Ocular Pathogens. Investigative Ophthalmology & Visual Science (ARVO Journal). In Press 2012.

Timothy P. Shiau, Eric D. Turtle, Charles Francavilla, Nichole J. Alvarez, Meghan Zuck, Lisa Friedman, Donogh J. R. O’Mahony, Eddy Low, Mark B. Anderson, Ramin (Ron) Najafi, Rakesh K. Jain Novel 3-chlorooxazolidin-2-ones as antimicrobial agents. Bioorganic & Medicinal Chemistry Letters 2011; (21) 3025-3028.

Eddy Low, Bum Kim, Charles Francavilla, Timothy P. Shiau, Eric D. Turtle, Donogh J. R. O’Mahony,Nichole Alvarez, Ashley Houchin, Ping Xu, Meghan Zuck, Chris Celeri, Mark B. Anderson, Ramin (Ron) Najafi, Rakesh K. Jain. Structure stability/activity relationships of sulfone stabilized N,N-dichloroamines . Bioorganic & Medicinal Chemistry Letters 2011; (21) 3682-3685.

Charles Francavilla, Eric D. Turtle, Bum Kim, Donogh J. R. O’Mahony, Timothy P. Shiau, Eddy Low, Nichole J. Alvarez, Chris E. Celeri, Louisa D’Lima, Lisa C. Friedman, Francis S. Ruado, Ping Xu, Meghan E. Zuck, Mark B. Anderson, Ramin (Ron) Najafi, Rakesh K. Jain, Novel N-chloroheterocyclic antimicrobials. Bioorganic & Medicinal Chemistry Letters 2011; (21) 3029-3033.

David Gerrish, In Chul Kim, Dange V. Kumar, Harry Austin, Jennifer E. Garrus, Vijay Baichwal, Michael Saunders, Rena S. McKinnon, Mark B. Anderson, Robert Carlson, Esther Arranz-Plaza, Kraig M. Yager. Triterpene Based Compounds with Potent Anti-Maturation Activity Against HIV-1. Bioorganic & Medicinal Chemistry Letters 18 (2008) 6377-6380.

Anderson, Mark B.; Roemer, Terry; Fabrey, Robyn. Progress in Antifungal Drug Discovery. Annual Reports in Medicinal Chemistry (2003), 38 163-172.
 


Neuroendocrine & Oncology


Jeffrey W. Lockman, Yevgeniya Klimova, Mark B. Anderson & J. Adam Willardsen. Synthesis of Substituted Quinazolines: Application to the Synthesis of Verubulin.  Synthetic Communications, 2012, 42, 1715-1723.


Nilantha Sirisoma, Azra Pervin, Hong Zhang, Songchun Jiang, J. Adam Willardsen, Mark B. Anderson, Gary Mather, Christopher M. Pleiman, Shailaja Kasibhatla, Ben Tseng, John Drewe, Sui Xiong Cai. Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure–activity relationship of the quinazoline ring (EP128495, MPC-6827, Azixa®).  Bioorganic & Medicinal Chemistry Letters, 2010, 20, 2330-2334.   

Paul R. Sebahar, J. Adam Willardsen and Mark B. Anderson. Anticancer Agents: VTA or VDA. Current Bioactive Compounds, 2009, 5(1), 79-97.

Nilantha Sirisoma, Azra Pervin, Hong Zhang, Songchun Jiang, J. Adam Willardsen, Mark B. Anderson, Gary Mather, Christopher M. Pleiman, Shailaja Kasibhatla, Ben Tseng, John Drewe, Sui Xiong Cai. Discovery of N-(4-Methoxyphenyl)-N,2-Dimethylquinazolin-4-Amine, A Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration. J. Med. Chem., 2009, 52 (8), 2341-2351.

Nilantha Sirisoma, Shailaja Kasibhatla, Azra Pervin, Hong Zhang, Songchun Jiang, J. Adam Willardsen, Mark Anderson, Christopher M. Pleiman, Ben Tseng, John Drewe, Sui Xiong Cai. Discovery of 2-Chloro-N-(4-Methoxyphenyl)-N-Methylquinazolin-4-Amine (EP128265, MPI-0441138) As An Inducer of Apoptosis with In Vivo Activity. J. Med. Chem. 2008, 51, 4771-4779.

Li, Haitao; Anderes, Kenna L.; Kraynov, Eugenia A.; Luthin, David R.; Do, Quyen-Quyen; Hong, Yufeng; Tompkins, Eileen; Sun, Eric T.; Rajapakse, Ranjan; Pathak, Ved P.; Christie, Lance C.; Vazir, Haresh; Castillo, Rosemary; Gregory, Margaret L.; Castro, Mary; Nared-Hood, Karen; Paderes, Genevieve; Anderson, Mark B. Discovery of A Novel, Orally Active, Small Molecule Gonadotropin-Releasing Hormone (GNRH) Receptor Antagonist. [ERRATUM TO DOCUMENT CITED IN CA145:020415]. Journal of Medicinal Chemistry (2006), 49(19), 5849. 

 Li, Haitao; Anderes, Kenna L.; Kraynov, Eugenia A.; Luthin, David R.; Do, Quyen-Quyen; Hong, Yufeng; Tompkins, Eileen; Sun, Eric T.; Rajapakse, Ranjan; Pathak, Ved P.; Christie, Lance C.; Vazir, Haresh; Castillo, Rosemary; Gregory, Margaret L.; Castro, Mary; Nared-Hood, Karen; Paderes, Genevieve; Anderson, Mark B. Discovery of A Novel, Orally Active, Small Molecule Gonadotropin-Releasing Hormone (GNRH) Receptor Antagonist. Journal of Medicinal Chemistry (2006), 49(11), 3362-3367.

Anderes, Kenna L.; Luthin, David R.; Castillo, Rosemary; Kraynov, Eugenia A.; Castro, Mary; Nared-Hood, Karen; Gregory, Margaret L.; Pathak, Ved P.; Christie, Lance C.; Paderes, Genevieve; Vazir, Haresh; Ye, Qiang; Anderson, Mark B.; May, John M. Biological Characterization of A Novel, Orally Active Small Molecule Gonadotropin-Releasing Hormone (GNRH) Antagonist Using Castrated and Intact Rats. Journal of Pharmacology and Experimental Therapeutics (2003), 305(2), 688-695.

Shackelford, Scott A.; Anderson, Mark B.; Christie, Lance C.; Goetzen, Thomas; Guzman, Mark C.; Hananel, Martha A.; Kornreich, Wayne D.; Li, Haitao; Pathak, Ved P.; Rabinovich, Alex K.; Rajapakse, Ranjan J.; Truesdale, Larry K.; Tsank, Stella M.; Vazir, Haresh N. Electrophilic Tetraalkylammonium Nitrate Nitration. II. Improved Anhydrous Aromatic and Heteroaromatic Mononitration with Tetramethylammonium Nitrate and Triflic Anhydride, Including Selected Microwave Examples. Journal of Organic Chemistry (2003), 68(2), 267-275. Erratum to CA138:169603 Journal of Organic Chemistry (2003), 68(7), 2986.

Iatsimirskaia, Eugenia A.; Gregory, Margaret L.; Anderes, Kenna L.; Castillo, Rosemary; Milgram, K. Eric; Luthin, David R.; Pathak, Ved P.; Christie, Lance C.; Vazir, Haresh; Anderson, Mark B.; May, John M. Effect of Testosterone Suppression On The Pharmacokinetics of A Potent GnRH Receptor Antagonist. Pharmaceutical Research (2002), 19(2), 202-208.

Luthin, David R.; Hong, Yufeng; Tompkins, Eileen; Anderes, Kenna L.; Paderes, Genevieve; Kraynov, Eugenia A.; Castro, Mary A.; Nared-Hood, Karen D.; Castillo, Rosemary; Gregory, Margaret; Vazir, Haresh; May, John M.; Anderson, Mark B. Characterization of Mono- and Diaminopyrimidine Derivatives as Novel, Nonpeptide Gonadotropin Releasing Hormone (GnRH) Receptor Antagonists. Bioorganic & Medicinal Chemistry Letters (2002), 12(24), 3635-3639.

 Luthin, David R.; Hong, Yufeng; Pathak, Ved P.; Paderes, Genevieve; Nared-Hood, Karen D.; Castro, Mary A.; Vazir, Haresh; Li, Haitao; Tompkins, Eileen; Christie, Lance; May, John M.; Anderson, Mark B. The Discovery of Novel Small Molecule Non-Peptide Gonadotropin Releasing Hormone (GnRH) Receptor Antagonists. Bioorganic & Medicinal Chemistry Letters (2002), 12(23), 3467-3470.

Pulmonary, Cardiovascular & Asthma


Kilgore, Kenneth S.; Powers, Karen L.; Imlay, Michelle M.; Malani, Anu; Allen, Douglas I.; Beyer, Jennifer T.; Anderson, Mark B.; Warren, Jeffrey S. The Carbohydrate Sialyl Lewisx (SLex) Sulfated Glycomimetic GM2941 Attenuates Glucan-Induced Pulmonary Granulomatous Vasculitis in the Rat. Journal of Pharmacology and Experimental Therapeutics (1998), 286(1), 439-446.

Kilgore, Kenneth S.; Tanhehco, Elaine J.; Park, James L.; Naylor, Keith B.; Anderson, Mark B.; Lucchesi, Benedict R. Reduction of Myocardial Infarct Size In vivo By Carbohydrate-Based Glycomimetics (GM1292, GM3290, GM1658). Journal of Pharmacology and Experimental Therapeutics (1998), 284(1), 427-435.

Kim, Mi-Kyeong; Brandley, Brian K.; Anderson, Mark B.; Bochner, Bruce S. Antagonism of Selectin-Dependent Adhesion of Human Eosinophils and Neutrophils By Glycomimetics and Oligosaccharide Compounds (SLex, GM1292, GM2296). American Journal of Respiratory Cell and Molecular Biology (1998), 19(5), 836-841.

Anderson, M.B., Kilgore, K.S., et al. Additional Novel Glycomimetics That Attenuated Glucan-Induced Pulmonary Granulomatous Vasculitis in the Rat. Unpublished.

Garcia-Criado, F. J.; Palma-Vargas, J. M.; Valdunciel-Garcia, J. J.; Gomez-Alonso, A.; Srivastava, O.; Ezrin, A.; Anderson, M. B.; Toledo-Pereyra, L. H. Sulfo-Lewisx Diminishes Neutrophil Infiltration and Free Radicals with Minimal Effect On Serum Cytokines After Liver Ischemia and Reperfusion (GM1998). Journal of Surgical Research (1997), 70(2), 187-194.

Musser, John H.; Anderson, Mark B.; Fugedi, Peter. Glycomimetics: An Approach To Discovering Leads For Novel Therapeutics. Pharmaceutical News (1996), 3(5), 11-17.

Musser, John H.; Fugedi, Peter; Anderson, Mark Brian; Rao, Narasinga; Peto, Csaba; Tyrrell, Dave; Holme, Kevin; Tressler, Rob. Carbohydrates as A Source of Molecular Diversity For Drug Discovery. Drug News & Perspectives (1996), 9(3), 133-141.

M. K. Kim, B. K. Brandley, M. B. Anderson and B. S. Bochner. Antagonism of Human Neutrophil (Neu) and Eosinophil (EOS) Adhesion By Glycomimetics and Oligosaccharide Compounds. The American Academy of Allergy and Immunology, abstract in J. Allergy Clin Immunol., 1995, 95:220.

Musser, John H.; Anderson, Mark B.; Levy, Daniel E. Glycomimetics as Selectin Inhibitors. Current Pharmaceutical Design (1995), 1(2), 221-32.

Rao, B. N. Narasinga; Anderson, Mark B.; Musser, John H.; Gilbert, James H.; Schaefer, Mary E.; Foxall, Carrol; Brandley, Brian K. Sialyl Lewisx Mimics Derived From A Pharmacophore Search Are Selectin Inhibitors with Anti-Inflammatory Activity. Journal of Biological Chemistry (1994), 269(31), 19663-6.

Natural Products


Anderson, M. B.; Lamothe, M.; Fuchs, P. L. Synthesis Via Vinyl Sulfones. 41. Cytochalasin, Natural Product Support Studies. 16. Intramolecular Acylation of An Alpha-?Sulfonyl Anion Generated Via Halogen-Metal Exchange of An Alpha-?Halosulfone Bearing An Unsymmetrical Anhydride. Tetrahedron Letters (1991), 32(35), 4457-60.

Lamothe, M.; Anderson, M. B.; Fuchs, P. L. Synthesis Via Vinyl Sulfones. 40. Cytochalasin, Natural Product Support Studies. 15. Scope and Limitations in The Use of Alpha-Silyl and Alpha-Stannyl Sulfones as Latent Alpha-Sulfonyl Anions. Synthetic Communications (1991), 21(15-16), 1675-93.

Wood, K. V.; Rothwell, A. P.; Anderson, M. B.; Fuchs, P. L. The Intramolecular Migration of A Trimethylsilyl Group Located Alpha To A Sulfone in Substituted Cyclohexyl Systems. Rapid Communications in Mass Spectrometry (1990), 4(1), 1-4.

Wood, K. V.; Rothwell, A. P.; Anderson, M. B.; Lamothe, M.; Fuchs, P. L. Mass Spectra of Substituted O-Trimethylsilylphenyl Sulfones. Organic Mass Spectrometry (1990), 25(8), 423-5.

Anderson, M. B.; Fuchs, P. L. Synthesis Via Vinyl Sulfones. 37. Cytochalasin, Natural Product Support Studies. 11. Alpha-Silyl Sulfones as Latent Alpha-Sulfonyl Anions. Fluoride-Promoted Intramolecular 1,2-Additions To Aldehydes as The Basis of A New Cyclopentenylation Strategy. Journal of Organic Chemistry (1990), 55(1), 337-42.

Anderson, Mark Brian. New Methodologies Directed Towards The Total Synthesis of Cytochalasin, Natural Product C and D. (1989), 498 pp. CAN 114:101467 AN 1991:101467.

Wood, Karl V.; Rothwell, Arlene P.; Anderson, Mark B.; Fuchs, P. L. Evidence For Competitive Intramolecular Trimethylsilyl Rearrangement To Oxygen and Sulfur in Beta-Trimethylsilylethylthiol Esters. Rapid Communications in Mass Spectrometry (1988), 2(2), 38-40.

Anderson, M. B.; Ranasinghe, M. G.; Palmer, J. T.; Fuchs, P. L. CYTOCHALASIN, NATURAL PRODUCT SUPPORT STUDIES. 10. Nucleophilic and Electrophilic Mercaptanylations Via 2-(Trimethylsilyl)Ethanethiol-Derived Reagents. Journal of Organic Chemistry (1988), 53(13), 3125-7.

Anderson, M. B.; Fuchs, P. L. Cytochalasin, Natural Product Support Studies. Part 9. An Efficient Method For Conversion of Carboxylic Acid Derivatives To Allylsilanes. Synthetic Communications (1987), 17(6), 621-35.

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